BioTechPlex Corporation

Product Lines	CardioDataPad® Version 2.2 A Real-Time Heart rate Variability (HRV) and Heart Rate Modulation (HRM) Analysis System: Assessment of cardiac autonomic function and cardiac chaotic behavior. (Please direct the inquiry to www.cardiacconnect.com) CardioDataPad® differentiates itself by providing physiologically relevant moment-by-moment time-frequency spectral analysis of ECG signals along with their non-linear chaotic behavior with numerics and graphics updated every 30 seconds. This time-frequency analysis provides 10 times the temporal resolution along with 2-4 times the sensitivity of the conventional indexes of heart rate variability, HRV, recommended by the European Task Force (also calculated by CardioDataPad®). CardioDataPad® has been extensively validated. CardioDataPad® provides: • Non-invasive indexes of sympathetic tone, parasympathetic tone, and their relative strengths • Beat-by-beat automated analysis of the power of the RR interval modulation frequencies of ECG signals as they are being acquired • Powerful baseline stabilization technology • Fast analysis of pre-acquired ECG data • Elimination of the need for editing the ECG prior to processing • Chaotic analysis of the ECG including a phase plot and chaotic index Correction for ECG BaseLine Baseline drift in ECG can obfuscate the reliable detection of R-wave peaks. An algorithm was developed to adjust the baseline in real-time prior to R wave identification. An example is shown in the following Figure. CardioDataPad® Applications • Cardiovascular Health: myocardial infarction, heart failure, hypertension, coronary artery disease, heart transplants, independent cardiovascular risk factors, and pacemaker evaluation • Diabetic Neuropathy: evaluation and monitoring of peripheral neuropathy and early detection of neuropathy in asymptomatic patients • Neurological Health: neurological diseases, syncope, circadian rhythm, clinical depression & anxiety disorders, and chronic fatigue syndrome • Sleep Apnea: evaluation of severity, evaluation of degree of autonomic dysfunction, and monitoring of treatment efficacy • Anesthesia: depth of anesthesia and effects of anesthetic agents on the autonomic nervous system • Physical Fitness and Wellness: sports medicine, exercise physiology, and aging • Drug Screening: evaluation of drugs which affect the autonomic nervous system • Safety Pharmacology: screening of new chemical entities (NCEs) for autonomic and cardiovascular side effects • Toxicological Screening: evaluation of the neurological and cardiovascular effects of chemicals • Biofeedback. *Disclaimer:* CardioDataPad® and data derived from it are solely intended for educational and research purposes. CardioDataPad® may not, under any circumstances, be used for clinical purposes to diagnose or treat any medical disease or condition. The user agrees to take all responsibility for the use of this software. Work Supported by NIH Grants - R43 NS 37981 and R44 HL 67735
> Physiological Measurements
> Ciliary Activity
> Heart Rate Variability
> Animal Respiratory Exposure
> Aerosol Generation
> Cell Lines
> Supporting Products
Licensing Opportunities
> Aerosol Drug Delivery
> Heart Rate Variability
> Miniature Pressure Sensor
Publications
Related Sites
Kaer Bio Therapeutics
CardiacConnect

Product Lines

CardioDataPad® Version 2.2

A Real-Time Heart rate Variability (HRV) and Heart Rate Modulation (HRM) Analysis System: Assessment of cardiac autonomic function and cardiac chaotic behavior.

(Please direct the inquiry to www.cardiacconnect.com)

CardioDataPad® differentiates itself by providing physiologically relevant moment-by-moment time-frequency spectral analysis of ECG signals along with their non-linear chaotic behavior with numerics and graphics updated every 30 seconds. This time-frequency analysis provides 10 times the temporal resolution along with 2-4 times the sensitivity of the conventional indexes of heart rate variability, HRV, recommended by the European Task Force (also calculated by CardioDataPad®). CardioDataPad® has been extensively validated.

CardioDataPad® provides:

• Non-invasive indexes of sympathetic tone, parasympathetic tone, and their relative strengths

• Beat-by-beat automated analysis of the power of the RR interval modulation frequencies of ECG signals as they are being acquired

• Powerful baseline stabilization technology

• Fast analysis of pre-acquired ECG data

• Elimination of the need for editing the ECG prior to processing

• Chaotic analysis of the ECG including a phase plot and chaotic index

Correction for ECG BaseLine

Baseline drift in ECG can obfuscate the reliable detection of R-wave peaks. An algorithm was developed to adjust the baseline in real-time prior to R wave identification. An example is shown in the following Figure.

CardioDataPad® Applications

• Cardiovascular Health: myocardial infarction, heart failure, hypertension, coronary artery disease, heart transplants, independent cardiovascular risk factors, and pacemaker evaluation

• Diabetic Neuropathy: evaluation and monitoring of peripheral neuropathy and early detection of neuropathy in asymptomatic patients

• Neurological Health: neurological diseases, syncope, circadian rhythm, clinical depression & anxiety disorders, and chronic fatigue syndrome

• Sleep Apnea: evaluation of severity, evaluation of degree of autonomic dysfunction, and monitoring of treatment efficacy

• Anesthesia: depth of anesthesia and effects of anesthetic agents on the autonomic nervous system

• Physical Fitness and Wellness: sports medicine, exercise physiology, and aging

• Drug Screening: evaluation of drugs which affect the autonomic nervous system

• Safety Pharmacology: screening of new chemical entities (NCEs) for autonomic and cardiovascular side effects

• Toxicological Screening: evaluation of the neurological and cardiovascular effects of chemicals

• Biofeedback.

Disclaimer: CardioDataPad® and data derived from it are solely intended for educational and research purposes. CardioDataPad® may not, under any circumstances, be used for clinical purposes to diagnose or treat any medical disease or condition. The user agrees to take all responsibility for the use of this software.

Work Supported by NIH Grants - R43 NS 37981 and R44 HL 67735

> Physiological Measurements

> Ciliary Activity

> Heart Rate Variability

> Animal Respiratory Exposure

> Aerosol Generation

> Cell Lines

> Supporting Products

Licensing Opportunities

> Aerosol Drug Delivery

> Heart Rate Variability

> Miniature Pressure Sensor

Publications

Related Sites

Kaer Bio Therapeutics

CardiacConnect