Small Animal Respiratory Exposure System (SARES™)
Designed to meet the rigorous demands of the toxicology, safety pharmacology and drug discovery industries 
SARES™ enables the measurement of respiratory, cardiac and autonomic responses to nose-only exposure of airborne agents in 12 rats. These measurements can be made in awake animals prior to, during and following acute exposure of the respiratory tract to aerosols or gases. The regional deposition of radiotagged aerosols can also be measured, as body temperature and other physiological parameters of interest .
SARES™ has the following features:
1. Provides nose-only zero dead-space exposure of aerosols and gases to the respiratory tract of 12 animals
2. Plethsymoplex™ enables the evaluation of respiratory function, prior to, during and following the exposure.
3. Graphical data output is provided by PhysioChart™, a virtual 12 channel Y-t recorder and
4. Calibration of each Plethsymoplex is achieved with its own piston pump.
5. Easy loading restraints for rats or guinea pigs
6. Facilitates quantitative measures of the dose delivered to each of the 12 animals.
7. It is made for use with toxic compounds.
8. It is robust and easy to clean
9. Comfortable physiological restraint
10. Provides physiological information in unanesthetized animals.
11. Has a minimum dead space with efficient aerosol delivery to all 12 animals.
12. Rotating chassis facilitates easy of operation and provides a small footprint.
13. Electrical feed-through bulkhead enables hard wired transmission of electrical signals into and out of the plethysmograph for expansion of the measurements of physiological functions
14. Electrical shielding for noise reduction
SARES™ Utility Options:
LinTePlex™: For the measurement of regional deposition of radiotagged aerosols.
TSAC™: A two stage aerosol concentrator with a 5µm cut-off pre-stage, for the delivery of concentrated 1-3 µm aerosols.
CardioDataPad® : For the simultaneous measurement of ECG and cardiac autonomic function.
Sales, Leasing, Technical Information, and Service Supports
Acknowledgements: The development of this system was supported by Grants R44 HL 61085 and R44 HL 67735 from the National Institutes of Health.
